I definitely don’t “get” all of the comics – although I suppose that’s true of any artform – but I do like and appreciate most of them. Especially if you like science you’ll enjoy this comic.
Make sure to hover your cursor over the comic after reading it. There is usually some additional background in the tool tip that will appear. Sometimes the tooltip can be a little long so Firefox users will need the “Long Titles” extension to get around a bug in that browser to let you see the whole thing.